Kevin Ginnever, Shaun Scott, Scott Preston, Kev Burton and Paul Biltcliffe will aim to complete it in 60 days.
Four of the riders are from Worksop and one is from Huddersfield, and they are doing it in aid of Bluebell Wood Children’s Hospice.
They all work for Sky, which has teamed up with Halfords for the expedition.
To sponsor them go to www.justgiving.com/jogle-relay-2013