The incident took place shortly before 11am on Leeming Lane in Mansfield Woodhouse at its junction with Peafield Lane and Sandgate Lane.
The lorry brought down a traffic light and barriers - but no other vehicles were involved in the accident.
Hundreds of alcoholic beverages, soft drinks and tinned items were left on the road as the HGV turned on its side.
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Sergeant Bailey from Nottinghamshire Police, who is at the scene, said they are still unsure why ot happened.
He said: “We can’t say what the cause is just yet, but we know the road will be closed for a few hours.
“No other vehicles were involved as far as we’re aware.”
The lorry driver is uninjured but has been taken to hospital for a check-up.
Council workers are also at the scene to repair the traffic light and barriers.
Drivers are advised to find alternative routes if possible.