The collision, which involved several vehicles, took place on the M1 northbound exit slip at junction J30 near Barlborough, just before 7am.
It was closed almost four hours and opened just after 10.30am
A Derbyshire police spokesperson said: "This incident occurred following a police pursuit by officers from Nottinghamshire Police and occurred at 6.50am this morning. It involved a collision between a car and a HGV on the slip road at junction 30.
"The road re-opened at 10.35am and an investigation into the circumstances of the collision is ongoing."