At its height, 20 crews from stations across Nottinghamshire, South Yorkshire and Derbyshire were in attendance at the blaze in Hermitage Lane, in Mansfield.
Firefighters from Worksop Station were at the blaze for more than five hours after being called to the scene at 3.14am.
Police remain at the scene working with colleagues from Nottinghamshire Fire and Rescue Service.
Drivers are being asked to plan alternate routes as Hermitage Lane remains closed.
The Robin Hood Line, which runs adjacent to the property has remained open.
Three men, all aged 18, have been arrested on suspicion of arson. They remain in custody.
2. blaze1.jpg
Firefighters were greeted by the building well alight. Photo: Nottinghamshire Fire & Rescue Service
3. Fire fighting
Nottinghamshire Fire & Rescue Service said the fire was tackled from the outside due to collapsing parts of the building Photo: Nottinghamshire Fire & Rescue Service
4. Devastation
At its height, 20 fire engines and two aerial ladder platforms were on scene. Photo: Nottinghamshire Fire & Rescue Service