At around 11.10pm on Friday, officers received a report of a vehicle leaving the A616 in Ompton, near Ollerton, and colliding with a house.
The driver of the vehicle, a 30-year old man, was taken to hospital for treatment for his injuries.
On Saturday morning, police said he was in a serious condition in hospital.
No other people were injured during the incident.
The road was closed for several hours to allow police collision investigators to carry out their work,
Anyone who witnessed the collision or who may have dash-cam footage of the incident should call Nottinghamshire Police on 101, quoting incident number 1039 of September 14, 2018.