A police cordon remains in place at the spot where a man was gunned down and another was injured in a shooting in Sheffield.
Officers are standing guard at the crime scene at the junction of Derek Dooley Way and The Parkway as inquiries into the double shooting continue.
The armed killer who struck at 10.15pm last night remains at large.
Police said the culprit fired into a car - killing the passenger and injuring the driver.
Both were taken to hospital by ambulance but the passenger - a 22-year-old man - could not be revived.
The 22-year-old driver of the car remains in hospital, where his condition is described as stable this morning.
Sheffield Hallam MP and Deputy Prime Minister Nick Clegg has urged anyone with information about the shooting to come forward.
He described the shooting as a ‘tragedy’.
Via Twitter he said: “Shocked to hear what happened in Sheffield. Any loss of life is a tragedy.
“I hope those with info will do all they can to help the police.”
Detective Chief Inspector Zaf Ali, responsible for tackling gun crime in Sheffield, said: “Any gun in criminal hands is one too many and any injury or loss of life is pointless and tragic, which is why we are determined to take guns off our streets on by one.”
He described a recent firearms amnesty as an example of the work being carried out in South Yorkshire to rid the streets of guns.
“The firearms amnesty was a national initiative and part of a long-term strategy to tackle gun crime,” he said.
“Officers carry out immediate and prompt action wherever possible to locate and confiscate firearms.
“Aside from that, we also carry out a significant amount of long-term work around educating young people in the county about the dangers of firearms and the consequences. We are also committed to working with our partner agencies to try and stop the flow of weapons.
“We also encourage the public to share intelligence with us relating to where these weapons are.”
Police initially closed Derek Dooley Way off in both directions but re-opened the road in time for rush hour this morning.
A South Yorkshire Police spokesman said: “A man has died, and another injured, following an incident in Sheffield city centre last night.
“It is believed the two men were shot at inside a vehicle on Derek Dooley Way at around 10.15pm before driving to the Parkway.
“They were taken to hospital, where the passenger inside the vehicle was pronounced dead.
“One other person inside the car remains in hospital in a stable condition. Both men are 22 and from the Sheffield area.
“No one has been arrested.
“Police would like to speak to anyone who witnessed the incident or to anyone who has any information that could help their enquiries.”
Workers for Capita, whose offices are based close to the scene of the double shooting, expressed their shock at their killing as they arrived at work this morning.
There was also police tape by the Capita building sign.
One member of staff said she had not heard what had happened before she arrived at work.
“I’m surprised, I didn’t really know anything up until now,” she said.
“It is unbelievable.”
Another worker, who asked not to be named, said he was also unaware of the incident before getting to work.
“It is pretty shocking,” he said.
Contact South Yorkshire Police on 101 quoting incident number 1,090 of December 21 or Crimestoppers, anonymously, on 0800 555 111.