The missiles were hurled at three articulated vehicles from steps leading to a bridge over the A57, near to the B&Q depot.
Each lorry was damaged and, on one occasion, a large brick narrowly missed a windscreen.
Worksop Inspector Steve Cartwright said: “The actions of these mindless criminals could easily have resulted in tragedy.”
“The bricks could have hit a windscreen, which would have effectively blinded the driver. This could have caused a massive collision and put people’s lives seriously at risk.”
“Whoever did this must have been aware of the damage and destruction they could have caused and it is only through sheer luck that we are not investigating a death today.”
“This senseless behaviour is completely unacceptable and simply will not be tolerated.”
A driver reported youths throwing bricks at his lorry at 10.40pm. When police arrived, they discovered two other lorries had been targeted earlier.
Witnesses should call Notts Police on 101 or Crimestoppers anonymously on 0800 555 111.