The 20-year-old had been behind the wheel of a blue Renault Clio when the accident happened on the A16 near Spalding in Lincolnsnhire at around 4pm on Friday.
The Clio was in collision with a Scania heavy goods Vehicle from Fleet Hargate. The driver of the lorry was not injured.
The woman died at the scene and the road was closed for several hours.
Police say the woman’s family has now been informed.
Police are appealing for witnesses to the collision, or persons who may have seen either vehicle on the road prior to it, to contact Lincs Police via the non-emergency 101 number or via the Collision Witness Hotline 01522 558855. Please quote incident number 253 of February 26.