The Office for National Statistics compared death rates from COVID-19 among people working in different professions.
It found there had been 45.7 deaths per 100,000 men working as security guards, compared to the national average for men of 9.9 deaths per 100,000 and for women of 5.2 deaths per 100,000.
Social care staff, including care workers and home carers, were also more likely to die from the disease, with a death rate of 23.4 for men and 9.6 per women.
For men, there was also a higher than expected death rate for taxi drivers and chauffeurs (36.4), bus and coach drivers (26.4), chefs (35.9) and sales and retail assistants (19.8).
Among healthcare workers, death rates were similar to the average, at 10.2 for men and 4.8 for women.
The ONS looked at the 2,494 deaths involving COVID-19 which had been registered up to April 20 among the working age population of England and Wales.
It found that men working in the lowest skilled occupations had the highest death rate, at 21.4.
Other professions with higher coronavirus death rates for men included process, plant and machine operatives (15.5), sales and customer service staff (14.3) and administrative and secretarial workers (13.9).
However, the ONS said the findings did not prove conclusively that the higher death rates in some professions were caused by increased exposure to coronavirus.